D-Mannose oligosaccharides
Mannose oligosaccharides are oligosaccharides formed by linking D-mannose to the main chain via β -1,4 glycosidic bonds, and connecting glucose to the main or branch chains, with a degree of polymerization between 2 and 10. It is a new type of prebiotic that can significantly activate and proliferate bifidobacteria and lactobacilli, regulating the balance of the microbiota.
Oligosaccharides have the characteristics of low calorific value, low sweetness, no caries, and no increase in blood sugar concentration, making them a new generation of functional foods.
Mannooligosaccharides (MOS) refer to oligosaccharides with a degree of polymerization between 2-10 linked by β -1,4-glycosidic bonds in D-mannose, also known as mannose oligosaccharides. It has the function of not being digested by the human gastrointestinal tract, but can promote the specific proliferation of intestinal probiotics represented by bifidobacteria in the body, inhibit the growth of harmful bacteria, reduce the generation of toxic metabolites, improve human intestinal function, prevent constipation, protect the liver, fight against tumors, and enhance immunity. It can be used as a food or feed additive and health food. By using endonuclease to hydrolyze mannan, oligosaccharides such as mannose disaccharides and mannose trisaccharides can be obtained.
Specifications：
| Product Name |
D-Mannose oligosaccharides |
| Appearance |
White or practically white powder |
| Molecular formula |
C6H12O6 |
| Molecular weight |
180.16 |
| Purity |
≥99.0% (HPLC) |
| Solubility |
2480 g/L (17 ° C), Transparent solution (10% aqueous solution) |
| Melting point |
127-133 ° C |
| Loss on drying |
<0.45 % |
| Heavy metals (as Pb) |
<10 ppm |
| Specific rotation [a]20/D |
+13.5°~ +14.9°(c=10, water) |
| Endotoxins (LAL) |
0.5 E.U. /1 ml 0.1% solution |
| Source |
Konjac Powder |
| Storage |
Room temperature |
| Technological function |
Sweetener |
| Applications |
Food or feed additives and health foods |
Method of Production ：
The methods of oligosaccharide separation and purification mainly include activated carbon column chromatography, yeast fermentation and gel column chromatography. The yeast fermentation method requires the screening of suitable yeast strains and a relatively simple sample composition. Gel column chromatography is effective and fast, but the cost of gel is very high, and the amount of sample is limited. Compared to others, activated carbon column chromatography has the advantages of low cost, good separation effect, large sample loading, and the ability to decolorize and desalinate, making it very suitable for preparing single oligosaccharide products.
The production methods of oligomannose mainly include extraction from natural raw materials, chemical degradation, and biodegradation. The post-processing of the first two methods is relatively complex, and the chemical method relying on acid-base hydrolysis has high cost and significant environmental pollution. The process of biodegradation is non-toxic and safe, with mild reaction conditions, low energy consumption, resource conservation, and environmental protection, making it the most ideal method for producing MOS. The enzymatic production of oligomannose is mainly limited by the low catalytic efficiency of the key enzymes used, the high production and usage costs of enzymes, and the difficulty in achieving high concentration production due to the high substrate viscosity. Therefore, in order to achieve industrial production of oligomannose by enzymatic method, breakthrough progress must be made in the research of key enzymes for hydrolyzing KGM.
Function：
1. Intestinal protection. The unique mannose receptor binding site preferentially binds to the mannose receptor on the surface of human intestinal cells, preventing pathogenic microorganisms from adhering to the intestinal mucosal epithelium of animals and achieving the elimination of pathogenic bacteria.
2. Adjust the balance of microecology. Mannose is not digested and absorbed by the human gastrointestinal tract, and directly enters the large intestine. It selectively provides a culture substrate for beneficial bacteria such as bifidobacteria in the intestine, rapidly stimulating the proliferation of beneficial bacteria, improving their vitality, improving the gut microbiota, and comprehensively enhancing various physiological functions.
3. Prevent constipation. Bifidobacterium ferments oligosaccharides to produce a large amount of short chain fatty acids, which can stimulate intestinal peristalsis, improve intestinal function, increase fecal humidity, and maintain a certain osmotic pressure, thereby preventing constipation.
4. Prevent obesity. Oligosaccharides are difficult to be broken down by enzymes in the digestive tract and are difficult for the human body to digest and absorb. According to measurements, its calorific value is below 1.5cal/g. After ingestion by the human body, it will not cause obesity. Meanwhile, due to its similarity to a water-soluble fiber, it can lower serum cholesterol and improve blood lipids.
5. Boost immunity. Oligosaccharides have immunogenicity, effectively stimulate immune responses, and can bind to the surface of toxins, viruses, and fungal cells, enhancing cellular and humoral immune responses, preventing bacteria and diseases.
6. Inhibiting the action of cancer cells. Normal fasting gastric juice contains 102-105 bacteria, and the destruction of the normal bacterial community can cause damage to the gastric mucosa, leading to gastric ulcers, as well as the colonization and proliferation of Helicobacter pylori, causing precancerous lesions such as gastritis, and ultimately leading to gastric cancer. Therefore, oligosaccharides may be an effective way to prevent and treat gastric cancer by regulating the imbalance of gastrointestinal microbiota (promoting the growth of beneficial bacteria, inhibiting the customization and reproduction of Helicobacter pylori) and directly killing or inhibiting gastric cancer cells.
7. Eliminate free radicals. The occurrence of many diseases is related to lipid peroxidation caused by free radicals (MDA is the final metabolite of lipid peroxidation, indirectly reflecting the degree of cell damage). Oligosaccharides can directly eliminate reactive oxygen species through complex reduction reactions, improve their activity through metabolic pathways in the body, and reduce the MDA content in plasma, liver, small intestine, and pancreas, which can prevent, control, or delay the occurrence of diseases.
Characteristic：
Oligosaccharides are the only novel functional oligosaccharides that can bind to exogenous bacteria in the intestine.
OEM&ODM Compound Sweetener:
We are a professional manufacturer of natural sweeteners. In addition to supplying regular D-Mannose oligosaccharides specifications, we can also provide you with the best sweetener solution according to your needs. At the same time, we can also provide composite and alternative sugar solutions based on your formula.
Certificates：
Package：
 |
 |
 |
|
5 Grams to 2kg
Packaging: Alu-bag
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5 KG/Al-Tin
Packaging: 2 pcs Alu-tin with box
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25 KG, Packaging: Drum
(54*37*37cm)=0.07CBM
N.W:25KG / G.W:28KG
|
Delivery：
01
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